Blog

Targovax ASA and Agenus Announce Collaboration on Mutant KRAS Cancer Vaccine Using QS-21 STIMULON™

The parties have entered into a collaboration agreement to develop Targovax's TG mutant KRAS cancer vaccines in combination with Agenus' QS-21 STIMULON adjuvant technology. The agreement may expand to an exclusive commercial partnership for the KRAS vaccine if the combination proves efficacy in exploratory clinical trials studies LEXINGTON, Mass., March 07, 2022 (GLOBE NEWSWIRE) -- Agenus (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, adjuvants, and more (Author: Gardener)

QS-21* The parties have entered into a collaboration agreement to develop Targovax's TG mutant KRAS cancer vaccines in combination with Agenus' QS-21 STIMULON adjuvant technology. * Agreement may expand to an exclusive commercial partnership for the KRAS vaccine if the combination proves effective in exploratory clinical trials LEXINGTON, Mass., March 07, 2022 (GLOBE NEWSWIRE) -- Agenus (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, adjuvants and vaccines to activate the immune response to cancer and infection; and Targovax ASA (OSE: TRVX), a clinical-stage immuno-oncology company developing immune activators to target hard-to-treat solids Tumore, today announce that they have entered into a clinical collaboration and supply agreement to combine Targovax's TG mutant KRAS cancer vaccines with Agenus' clinically validated and FDA-cleared QS-21 STIMULON adjuvant. The TG vaccines are peptide mixtures designed to elicit polyvalent immune responses against the most common mutations in the RAS gene family, which cause up to 30% of all cancers. TG01 has shown promise in phase 1/2 clinical trials and Targovax has recently been awarded two prestigious research grants providing up to NOK 18 million in funding to advance the TG programme. Cancer vaccines require combination with an adjuvant to stimulate antigen processing and T-cell priming, and Targovax has selected QS-21 STIMULON as the adjuvant of choice for further clinical development. It has been extensively studied in over 120 clinical trials and has consistently demonstrated strong antibody and cell-mediated immune responses and a favorable safety profile. QS-21 STIMULON is a key component of several vaccines, including GSK's FDA-approved shingles vaccine Shingrix® with more than 9 years of protection and the world's first malaria vaccine Mosquirix™. As part of the collaboration with Targovax, Agenus will provide QS-21 STIMULON and scientific support for up to three initial clinical trials of TG01 in multiple cancer indications. If clinical results meet certain pre-determined performance targets, the collaboration will be expanded into an exclusive pivotal development and commercialization agreement in which Agenus is entitled to tiered double-digit royalties on future sales of TG vaccines. Armen, Chief Executive Officer of Agenus Inc., said, “We look forward to working with Targovax to extend the benefit of QS-21 STIMULON to new patient populations, such as those with KRAS mutant cancer. It underscores the broad applicability of our QS-21 STIMULON technology and could open up a significant commercial opportunity in KRAS mutant cancers.” Erik Digman Wiklund, Chief Executive Officer of Targovax ASA, added: “QS-21 STIMULON is arguably the most clinically and commercially successful FDA-approved adjuvant for protein and peptide-based vaccines and has been shown to be highly effective in eliciting immune responses. We anticipate that this unique adjuvant will further enhance the efficacy of our TG01 and TG02 products and see it as a critical part of our development strategy as we prepare to bring the TG vaccines back into KRAS multiple mutant cancers E-mail: [email protected] Activating Patients' Immune Systems to Fight Cancer Targovax (OSE:TRVX) is a clinical-stage immuno-oncology company developing immune activators that target hard-to-treat solid tumors aim Targovax's focus is to activate the patient's immune system to fight cancer, thereby helping cancer patients with few treatment alternatives available. Targovax is evaluating its product candidates in multiple cancer indications, including melanoma, mesothelioma and colorectal cancer, and has demonstrated a favorable safety and tolerability profile. Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The company's vision is to expand patient populations who benefit from cancer immunotherapy by pursuing combination approaches utilizing a broad repertoire of antibody therapeutics, adoptive cell therapies (through its subsidiary MiNK Therapeutics), adjuvants and proprietary cancer vaccine platforms. The Company is equipped with a range of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. For more information, please visit www.agenusbio.com and our twitter handle @agenus_bio. This press release contains forward-looking statements made pursuant to the safe harbor provisions of the US federal securities laws, including statements regarding clinical development and regulatory approval plans and timelines, anticipated corporate milestones, new clinical data and program updates to be presented. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. Agenus cautions investors not to place undue reliance on the forward-looking statements contained in this press release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise any statements, except as required by law.

Read

'Blue Bloods' cast answers more of your questions about Burning Season 12

Wasn't your question answered in the TVGM cover story? Find out here if they made it! (Author: Gardener)

Blue Bloods'For fans who have submitted questions to the Blue Bloods cast and Executive Producer Kevin Wade, who didn't see their entries in the TV Guide Magazine cover story - and for the rest of you Friday Night Cop/Family series lovers – we have a treat ! Read below for some more of the many questions we received on BB's 250th episode, along with answers from Tom Selleck, Donnie Wahlberg, Bridget Moynahan, Will Estes, Vanessa Ray, Marisa Ramirez and the aforementioned EP Calf. It's not a question, but I want to tell Tom how much I love Frank's brain trust Baker (Abigail Hawk), Gormley (Robert Clohessy), and Garrett (Gregory Jbara)! Tom Selleck (NYPD Police Commissioner Frank Reagan): I love her! They are all good friends. You know, at the beginning of the show I think they pictured me on the street directing military operations against the bad guys. I told them if Frank has to prove he's boss all the time, then you've cast the wrong guy. I'm so proud to have Abigail. She had a line on the show (announcing a visitor to the police commissioner's office) and I was frustrated because I didn't have an aide to talk to. We go back to the elevator, I get off and we talk.” She did, and I could tell that she was a trained actress. For the audience, I think she's Radar in M*A*S*H. She really knows what's going on. She, like Garrett, has now earned an irreplaceable position at 1PP. I worked with Greg on In and Out - a great film - and I put him in a couple of pilots that I produced that didn't sell. So I figured I needed an assistant public information officer alongside Baker and suggested Greg, who had just won a Tony. And then I got Robert Clohessy, who plays Sid. He was Danny's boss and I had a scene with him when Danny had a problem. So I spoke to Donnie and Kevin Wade. I said, "Frank is so concerned about losing touch with the base - which is why he got the job - that he wanted someone to remind him. And he brings Gormley in.” This universe allowed us to tell what happens when the commissioner's office door closes, because his stories are different from the stories on the street. They got close to the karaoke scene. Donnie Wahlberg (Det. Danny Reagan): The karaoke scene was so well received that Danny was bound to sing again at some point. Why is Danny the only one who actually eats some of the meals in the Sunday lunch scenes? Wahlberg: Danny probably eats the most because Donnie is the hungriest. But seriously, Danny's kind of a cop in a china shop. The best way to play this at dinner is to talk a lot with your mouth full. How many of the main cast have seen Donnie Wahlberg in concert with NKOTB? Wahlberg: I ​​think nine. But I'm still trying to get Tom and Len [Cariou] to come. Marisa Ramirez (Det. Maria Baez): It would be fun to see everyone together at a show. My first NKOTB concert was in 7th or 8th grade with some of my friends and our moms at Dodger Stadium. Ever since I started working with Donnie it's been so much fun to revisit that part of my life every time I see her in concert again. I think I've been to five shows in the last nine years. I hope to see more of [Erin's ex-husband] Jack Boyle (Peter Hermann) this season. Bridget Moynahan (Head of Negotiations Office Erin Reagan): We had a couple of scenes with Jack Boyle that really felt like something was cooking there. I want to say that off-screen it's still boiling. And I want to say that they would bring him back next season! When we have a next season. I don't know if we do, but hopefully Jack Boyle will come back. I love working with him. I always think they have such beautiful on-screen chemistry. And he came to the family dinner! That was such a nice scene where he would sit down and stuff. Could there be a fast forward when Jamie becomes a police commissioner in the future? Will Estes (Sgt. Jamie Reagan): Jamie Reagan will probably be the P.C. someday, but I'm not sure he'll ever fit into the structure of these Blue Bloods. Who is the prankster in the cast? – Karlene Kincaid Estes: Vanessa and I laugh together all day. It's just the nature of our friendship at this point, and I think it drives us through the day. We often deal with heavier issues in front of the camera, so maybe it's a balancing act. I can imagine that from the outside it might look like we're joking, but we're both very focused on our performance. Why do newlyweds Eddie and Jamie never kiss and hug? Vanessa Ray (Officer Eddie Janko): There's been a few hot kisses over the years! But so often we see her at work and at the Reagan family dinner table where PDA doesn't feel appropriate. It's all in the flirtatious eyes for these scenes. What performers ruin a take by cracking up? Ray: I don't want to name names, but historically there's a specific end of the table that has the church giggling around hour 2 of filming the dinner scenes... I may or may not be at that end of the table. (I'm absolutely at that end of the table.) Will we ever see an episode that focuses a little more on Baez's backstory? She's my favorite, but I feel like we don't actually know much about her. Ramirez: I would also like to know more about Baez's backstory. We had some little glimpses of family life with the couple of episodes of her brother Javi and a scene with her mother and sister but sadly we didn't see them again. It's fun that Baez is a bit mysterious. Maybe she has some deep dark secrets that we can one day uncover, or some deep layers that we can peel off and really get to know her. Executive Producer Kevin Wade: Absolutely! Nicky and Jack will definitely show up. Why were there so many people named Jack on the show? Besides Danny's son and Erin's ex, are there any other guest characters named Jack? Wade: Lazy writing. I would have to check and verify your account but I wasn't aware that we used so many jacks. I will pay attention to that in the future.

Read

Beware the ides of March madness

Hackers have countless ways to trick you into engaging with them. These tricks include promises of bigger wins or inside information about teams. (Author: Gardener)

MarchTechNewsWorld's full-service marketing programs deliver sales-ready leads. Get started now. TechNewsWorld's full-service marketing programs deliver sales-ready leads. Get started now. Don't lose your jersey when betting on teams participating in the NCAA March Madness basketball tournament. This annual event is a very popular time for betting communities and tournament challenges - when employees often use websites, online platforms or shared spreadsheets to organize. According to Hank Schless, senior manager of security solutions at endpoint-to-cloud security company Lookout, these tricks include promises of bigger profits or inside information about teams. “Threat actors see this event as low-hanging fruit for social engineering and phishing. They can easily spoof the URL of popular sports and betting websites like ESPN, DraftKings and FanDuel,” he told TechNewsWorld. Recently, there have been numerous reports of attackers using fake Google Drive and Office 365 sharing links to trick corporate users into revealing their credentials. Phishing has become the most popular method for attackers to gain access to corporate infrastructure. "But that also poses risks when your IT and security teams don't have visibility into the context in which users are accessing apps and data," he said. Cyber ​​attackers use events like March Madness to lure their targets and trick them into ignoring any red flags that indicate malicious intent. When it comes to credential phishing, a simple text or social media message can be very effective, Schless observed. Protect yourself against the risk of unauthorized users gaining access to your sensitive data. Use security software to detect and block phishing attacks and web traffic from any device to disrupt connections to malicious websites. “Additionally, you need visibility into the context in which users are logging into your infrastructure and accessing data. Abnormal locations, devices, and number of login attempts can all be indicators of compromised credentials,” he said. All major sporting events can lead to a rise in phishing scams, fake domains and adware, admitted Jasmine Henry, field security director at cyber asset management and governance firm JupiterOne. "March Madness poses a unique risk for employers because it occurs during business hours when fans are generally using work-related devices and network resources," she told TechNewsWorld. Security officials should consider whether a brief update to their acceptable use policy might reduce March Madness's security risks, she suggested. When official NCAA and ESPN websites are blocked on the network, sports fans will find alternative ways to watch the streams and may use more patchy, malware-ridden websites to circumvent the policy. "Security professionals should also talk to users about what risks they should look for in their inboxes and text messages, including links, attachments, and clip invites sent by a threat actor rather than a co-worker," Henry suggested. March Madness' chaotic atmosphere provides the perfect cover for evil actors looking to commit cybercrime. According to Ray Kelly, Fellow at NTT Application Security, popular sports and betting apps tend to do a good job of fixing critical vulnerabilities once they are identified. "However, March Madness fans will need to ensure they update mobile apps frequently, as security fixes within those updates will be made available through the App Store and Google Play," he told TechNewsWorld. Users' personal information is more likely to be compromised through targeted email or SMS phishing campaigns. It's relatively easy for hackers to craft emails or landing pages that look legitimate and trick users into entering their personal information on a malicious website, he explained. “A good rule of thumb is to never open links sent via email. In fact, it's much safer to always go straight to the website or mobile app," Kelly urged. Just before March Madness, professionals and sports fans alike are starting to prepare schedules to fill out their brackets and stream the games online. We think little about security, observes Joseph Carson, chief security scientist and consulting CISO at privileged access management (PAM) provider Delinea. We like to click on things. Always use caution when receiving messages containing a hyperlink, he told TechNewsWorld. Occasionally check with the sender to make sure they actually sent you an email before aimlessly clicking on what could be malware, ransomware, a remote access tool, or a virus stealing your data or on your data access, suggested Carson. “Before clicking, everyone needs to stop and think. Check the URL, make sure the URL uses HTTPS, and also verify that this URL is from a legitimate source," Carson said. "Find out where the hyperlink takes you before you click, because you might be in for a nasty surprise." There might be a retro experience worthy of keeping safe this March Madness season, Richard Fleeman warned , Vice President of Penetration Testing Ops at cybersecurity consultancy Coalfire. “Consider managing pools of offices using old-school methods of manual tracking and having one person coordinate. If you're using a document to track, you should share that document through Box, Google Docs, etc.," he told TechNewsWorld. Consider using known and trusted platforms for March Madness brackets, tracking, betting and spreads. Use multi-factor authentication, use a password vault to generate unique passwords, verify email headers and URL links. Don't open unfamiliar attachments, bookmark, or log into the online platform directly instead of clicking links in an email, etc. Be wary of applications that use common authentication frameworks and third-party trusts - Google Auth or Facebook - without verifying the elements that are requesting or trusting access. Blindly allowing access and trust could potentially compromise your accounts.

Read

Harry Maguire accidentally HEADS Cristiano Ronaldo on a corner

Maguire struggled again with another poor defensive performance and was ironically cheered by some home fans when he was replaced by Juan Mata. (Author: Gardener)

Harry MaguireFootage has emerged showing Harry Maguire accidentally colliding with Cristiano Ronaldo in Manchester United's loss to Atletico Madrid. The duo endured a night to remember as United's last chance at trophies vanished with a 1-0 defeat at Old Trafford and a 2-1 aggregate loss to the Spanish champions in the Champions League round of 16. Maguire struggled again with another poor defensive performance and was ironically cheered by some home fans when he was replaced by Juan Mata with six minutes left. Maguire clashing with Ronaldo and then slamming himself in the face with Mandava's hand is the most slapstick thing I've seen in football in years pic.twitter.com/8yYdQylVM1 - BRACE - Newcastle United Discussion (@NUFCBrace) March 15, 2022 His However, his most awkward moment came when he seemingly accidentally banged his head against his own team-mate's as United tried to score in a dangerous area from a set piece after 66 minutes. Maguire - a threat from set pieces - tried to stop a couple of Atletico Madrid players to make room for either himself or his Portuguese team-mate Ronaldo to test goalkeeper Jan Oblak. But the England defender only managed to leave the 37-year-old feeling slightly uneasy, jerking his head back and then colliding with Ronaldo, who was clutching his teeth in pain moments later. However, the comedic element of that passage seemed to reach a new level as Maguire appeared to smack himself in the face with Atletico defender Reinildo Mandava's hand. Ronaldo covered his mouth again because the ball was out of play. The England defender's actions resulted in the 37-year-old Portuguese clenching his teeth in pain after a slap to the face, but was then seen again uncomfortably covering his mouth because the ball was out of play. Fans on social media were instantaneously poking fun at Maguire for the bizarre incident, with one posting: "The headbutt is great but the fact that Maguire hit himself is even better." Another added: "Best thing Maguire did all night was headbutt Ronaldo...lol." Best thing Maguire did all night was Ronaldo with the headbutt...lol - Depressive Mode (@XwisebloodX) March 15, 2022 probably could have scored with that free kick if Maguire hadn't headbutted Ronaldo ffs - Mannchunian (@mannchunian) March 15, 2022 Only Maguire would headbutt Ronaldo before going for the header. This season's bloopers are going to be our biggest ever.— Sun 🇮🇷 پسر خورشید 🦉 (@1Afshin) March 15, 2022 That moment when Maguire accidentally headbutted him and delayed his run, stopping him from hitting the back post going in just sums us up- . However, other United fans believed their side prevented an equalizer after Renan Lodi's header in the first half, commenting: "Probably that free-kick could have scored if Maguire hadn't head-butted Ronaldo." Other United fans believed it was typical of their upside-down season, with another adding: "That moment when Maguire accidentally headbutted him and delayed his run and prevented him from getting in at the back post, just sums us up." However, others could only see the funny side, with one stating: "Only Maguire would headbutt Ronaldo before going for a header. This season's slip-ups will be our biggest ever.' However the fans saw it, it was another night in which Maguire and United failed to excite as their last chance to end their trophy drought since 2017 eluded them . The defender was ironically cheered for Juan Mata (right) in the 84th minute of defeat and ex-Liverpool defender Jamie Carragher believes time is ticking for Maguire to retain his place at Old Trafford. "The £80million Manchester United captain was dropped at the game," Carragher told CBS Sports. "He's going through the worst moment of his career right now. We all have that moment, I can imagine it now when I was playing. “It's something Harry Maguire is going through right now and he needs to come out very quickly otherwise he won't be at the club because the standards at Manchester United are so high. Maguire struggled again in defense as United's last chance for a silver this season slipped away. “Of course he wants [to come out] but his head will be everywhere, he will be criticized from left, right and centre. "I've always been a fan of Harry Maguire. Virgil van Dijk cost £75m and is the best defender in the world. "Harry Maguire isn't, but he doesn't set the price.

Read

Rashford loses spark as club and country status wanes

Break the news by Associated Press LONDON: It wasn't long ago that Marcus Rashford was widely and affectionately regarded as English football's national treasure. For Manchester United it is the team's biggest game of the season so far - an elimination (Author: Gardener)

Associated PressHowever, this week will underscore his declining status for both club and country. For Manchester United it is the team's biggest game to date - an eliminator against Atletico Madrid in the Champions League round of 16 on Tuesday. Two days later, England name their squad for the friendlies against Côte d'Ivoire and Switzerland, coach Gareth Southgate's third-last selection, before picking the players to represent the country at the World Cup in Qatar. The 24-year-old striker has not played a minute for his country since his penalty shoot-out in the EURO final's penalty defeat by Italy in July. And over the past eight months, Rashford has gradually slipped down the attacking pecking order at United. So much so that a week ago he failed to start in a derby game against Manchester City despite the club's four forwards - Cristiano Ronaldo, Edinson Cavani, Mason Greenwood and Anthony Martial - being unavailable for various reasons. That possibility was raised by United manager Ralf Rangnick last week. "Even assuming he and his agents or his family think about maybe moving to another club at some point in the summer, then he can do that," Rangnick said, "but in the summer." One of the regulars in United's team under then-coach Ole Gunnar Solskjaer, he was Britain's talking point off the pitch too, after twice forcing the government to do an about-face on its welfare policy during the pandemic over its campaigning for vulnerable children. "Future captain, maybe of England and Manchester United." So the slide in his career has been strong. After being one of three players to miss a penalty – and later being racially abused online – on that fateful night against Italy at Wembley on 11 July, Rashford was sidelined for four months following shoulder surgery. He had played with pain last season as he played 64 games for club and country, raising the potential of suffering from burnout. Confidence is clearly an issue - the swagger of recent years is gone, as is the joy in his game - while ever more threats to his place in United's forward line have emerged. Rashford, now considered a wide forward, was passed by Greenwood early in the season. In recent months, Jadon Sancho has settled at United for good after his $100m off-season move from Borussia Dortmund and is one of the few players to have found real success under Rangnick's shift in style and approach. Rashford has started just three of United's last 12 Premier League games, most recently in Saturday's 3-2 win over Tottenham when he was substituted after 67 minutes to be replaced by Elanga. The 19-year-old Swede also came on for Rashford in the first leg against Atletico, scoring the equalizer in the 1-1 draw. Sancho and Elanga show more dynamism and energy than Rashford, while their pace of work seems more suited to Rangnick's pressing game. It is very likely that they will start the second leg at Old Trafford. Rangnick clearly sees something in Rashford - "he's got a lot of talent," the Germany coach said, "he's got almost everything you need for a modern striker" - but says it's now about "putting the power of the training sessions into the regular games.” For now, at least, the spark has come from a player who was urged by Solskjaer in October to “make his football a priority” in the face of the challenges of playing for United and England after all the notable ones Things he's done, done off the pitch. Time will tell if this is just a minor blip in a career that has promised so much. Either way, this week could be a sobering one for Rashford.

Read

Man Utd urged to sign Chelsea star as Gary Pallister sends message to Marcus Rashford

"You can't have too many good players in your squad" (Author: Gardener)

ChelseaGary Pallister has advised Man Utd's Marcus Rashford (Pictures: MUTV/Getty) Gary Pallister has urged Manchester United to exploit the crisis at Chelsea by signing Antonio Rudiger and has given his advice to Marcus Rashford as he considers closing Old Trafford leaving . Germany defender Rüdiger is expected to leave Stamford Bridge at the end of the season along with the likes of Cesar Azpilicueta and Andreas Christensen. Rudiger has made 189 appearances for the Blues and was one of the stars of Chelsea's Champions League win last season and their Club World Cup triumph earlier this year. Real Madrid and Bayern Munich are believed to be leading the race to land Rudiger, but Premier League giants United have also been linked with a move. Former Manchester United defender Pallister is an admirer of Rudiger and says he would welcome his arrival at Old Trafford, although insists he hopes the Red Devils decide not to sack struggling captain Harry Maguire. "You can't have enough good players in your squad," Pallister BoyleSports. “If Rudiger was available for free and he was interested in Man United, I'm sure they would look at it. United have been linked with Chelsea contract rebel Antonio Rudiger (Image: Getty). "I wouldn't try to sell Maguire, but if you can add quality like Rüdiger, add quality. He's a no-nonsense defender and has shown he has quality on the ball and getting him on a free transfer would be a good deal.” To Maguire, who has had a hot season and featured in Saturday's 3-2 win over Tottenham Own goal scored, Pallister added: “There's no getting away from the fact that he's not at his best. "People say he hasn't done this or that, but I think he's been the natural leader for United in recent seasons. “I think he was pretty good in a United shirt up until this season. I think he will return to his very best and I think he and [Raphael] Varane will be the back end partnership going forward. "There are factors as to why he's had a dip, but ultimately Harry has been quite good and he's the only one who seems to be the natural leader in the dressing room. I've played with four, five captains on the teams I've played on and I don't see too many natural leaders with this character and when things are difficult in games these characters can guide you through moments in games, and at the moment we don't have that has made them leaders on the pitch.” Another player linked with a move from Manchester United is England striker Rashford. The 24-year-old is said to be reflecting on his future at the club after slipping down the pecking order at Old Trafford and being benched for the recent Manchester derby. When asked about Rashford's future, Pallister said: "If players don't want to be at Manchester United, wow. 'Marcus came through Manchester United academy, he's a Manchester United boy and I'm sure he will want to stay and be a big part of the club because there's no doubting the boy's talent. “He proved it in a Man United shirt, proved it for England. He's going through a tough time and has done a lot of wonderful things away from football which has perhaps been a distraction.” Visit our sport page for more stories like this.

Read

Marcus Rashford must refute Jamie Carragher's prediction to revive Manchester United's career

As Rashford ponders his future at Old Trafford, he risks following a path followed by many of his predecessors in recent years. (Author: Gardener)

Marcus RashfordManchester United are in an all too familiar position with Marcus Rashford. For this once all-conquering club, this is yet another sad indictment of their downfall over the past 10 years. United made their mark as the club to buck the trend under Sir Alex Ferguson. Alan Hansen's oft-cited phrase that 'there's nothing to be gained by children' has been regularly debunked as the Old Trafford assembly line kept producing exciting and new talent. The club have continued to produce their own players since Ferguson's retirement but none have managed to match the longevity of those names of the past. In fact, most have followed a very similar pattern: rushing onto the stage, struggling to keep that early momentum going, finding themselves over and over again as a team, before finally fading into oblivion as they leave Old Trafford. It's a beaten path for many of the players that fans have had such high hopes for. So many had predicted Rashford would be the one to break the trend - but even he now finds himself in a state of purgatory at the club. Though he'd be reluctant to leave his boyhood club, even that bond hasn't stopped other names from saying goodbye. A striker who was United through and through, he was forced to reluctantly leave the club in 2014 after finding a place for him in the squad became increasingly difficult. It's not a new comparison either. Back in 2018, Jamie Carragher drew parallels between the two when discussing the possibility of Rashford leaving the club for more playing time. "I like Danny Welbeck as a player and I hope that doesn't come across as disrespectful, but Marcus Rashford doesn't want to be Danny Welbeck. “By that I mean he came through at United as a centre-forward, then was deployed on the left and then on the right, he was delighted to get minutes and all that stuff. But he ends up becoming a squad player who never nails a center forward position, he moves to Arsenal and exactly the same thing happened, where is he playing? That description will sound a little too close to home for Rashford and United fans. Early suggestions that he would become the Reds' next big centre-forward were dashed as left flank became his preferred position. This season he has been pushed to the right with the arrival of Jadon Sancho, although even that position has now been threatened by Anthony Elanga. Rashford's poor form this season has been a major concern and with the 24-year-old now weighing his options there is a real concern he could follow the same path as Welbeck. Rashford has one more year on his contract at Old Trafford, after which United have the option of an extra year should they wish to take advantage of it. But with changes at the club over the summer and Ralf Rangnick refusing to rule out a Rashford exit, the player may have just a few months to prove his worth and dissuade the club from letting go of another of their own. All his great work off the pitch means there are few who would want to see Rashford United leave. Now it's up to him to finally break this trend at the club. Sign up for our United newsletter so you don't miss an update from Old Trafford this season.

Read

What happened to Rashford? The Man Utd star's slump is a symptom of a club with no identity

Marcus Rashford hasn't been at his best in around a year, with his performances under Ralf Rangnick being some of his worst in a Manchester United shirt - so what went wrong? (Author: Gardener)

RashfordIt's no wonder reports surfaced last week that Marcus Rashford is seriously considering his future at Manchester United. Ralf Rangnick has clearly not opted for the England striker since arriving at Old Trafford in November, but relations between the two hit a new low in the Manchester derby when Rashford remained on the bench - relegated in the pecking order below Jesse Lingard and unable to get minutes even with Cristiano Ronaldo and Edinson Cavani out injured. If Rashford's place in the starting XI against Tottenham on Saturday was a reset opportunity, he hardly grabbed it with both hands. The 24-year-old touched the ball just 30 times before being substituted off in the 67th minute without a single shot, dribbling or key pass. Rashford has been in poor form for arguably a year, his trademark explosiveness – those instinctive, decisive moves in the last third – fading as his lack of confidence drains his energy. He's a hesitant player now, drifting through games too often, either playing easy ball or trying too hard to get back into his manager's good books. "In Marcus Rashford we have another player that I will insist on and who will continuously be behind him and with him to develop," Rangnick said ahead of the Man City game. "I will put all my energies into helping him follow the same path that other players have taken over the past three months." It is telling that some reports cite a source close to Rashford as making the claim , the striker wants more clarity on the club's future. In a way, this is a message being sent to the United hierarchy; a call for more certainty about the club's future and perhaps a not-so-subtle warning that Rangnick should not be the man in charge next season. Regardless of what those reports really mean, there's every reason to sympathize with Rashford, who missed the first two months of the season through injury and - like so many others - struggled to understand the Rangnick methodology - it was in and out of it teams since. Tactically, the main reason for Rashford's steady decline is the lack of focus, clarity and specialization bestowed upon the player. This starts with the fact that Rashford is yet to establish his own position. Rashford has developed into a jack of all trades and is no master of what can really only be attributed to the poor quality of coaching he has received in recent years. We already know that little coaching took place during Ole Gunnar Solskjaer's three-year tenure. According to one report, after a long period of not knowing what the manager wanted from him, Rashford plucked up the courage to confront Solskjaer, only to be told to stop whining. Previously, Jose Mourinho and Louis van Gaal asked Rashford to play in completely different ways, a problem that has plagued every senior United player who has survived for so long. Most young players of Rashford's talent would have been formed and honed in their early twenties; You'll receive in-depth coaching to sharpen blunt aspects of your game and ongoing advice to nurture the aspects that come naturally. Instead, Rashford was allowed to drift and drift as a symbol of everything else at the club. In theory, Rashford - at least at his best - should work in a Germanic system like Rangnick's, and it should be noted that he may simply need a consistent run on the team at a single position. According to FBRef, Rashford is averaging .58 goals and assists per 90, which is right in line with his career average. In fact, practically across the board -- from defensive to creative stats -- Rashford is only very slightly below his career averages. A resolution is unlikely to be found this year, but with a fresh appointment in the summer there is a chance for a reset and an arm-around-the-shoulder approach - something Rashford, a real national treasure for his off- Field activities, at least deserved. Trying to get the best out of Rashford is another reason for United to hire Mauricio Pochettino, who was reportedly keen on signing Rashford as Tottenham manager. Pochettino's detailed coaching methods coupled with his desire to play attacking football quickly and his history of strong relationships with players make him a good candidate for Rashford. Rashford needs a manager who believes in him, who knows what he wants from a player and gives him a consistent run at a position. He could also use a manager to actually coach him and bring out those clinical instincts that we saw from the United Academy graduate when he first broke into the team. That player still exists but like everyone else at Old Trafford in recent years, Rashford has slowly been lost. It would be Manchester United's failure and a damning indictment on the club's leadership if Rashford left the club.

Read

Manchester United after losing at home to Atlético Madrid from the Champions League

Ralf Rangnick's Red Devils saw their final path to cutlery slammed by Diego Simeone's wily, well-trained side on Tuesday night. (Author: Gardener)

Manchester UnitedManchester United will end a fifth straight season without a trophy after being knocked out of the Champions League at home by Atletico Madrid. Ralf Rangnick's Red Devils, long since eliminated from the Premier League title race, saw their final path to silverware slammed by Diego Simeone's wily, well-trained side on Tuesday night. United could not build on the barely deserved draw in the first leg of this round of 16 duel in Spain. Renan Lodi's first-half header secured Old Trafford a 1-0 win as Atleti progressed to the quarter-finals. The 2-1 aggregate result dashed any faint hopes of a first silver medal since the 2017 Europa League, when the Premier League side ended a continental season in defeat by Spanish opponents for the fifth consecutive season. United started well enough in a rocking Old Trafford, where Anthony Elanga would have scored his second had Jan Oblak not been happy on a night the reigning LaLiga champions would have grown into. Joao Felix scored a header in the first leg and saw a first-half goal ruled out for offside just before Antoine Griezmann hooked a cross to the back post for Lodi to head home. It was a gut punch United didn't respond to as Simeone's side sat low, building pressure in the second half and frustrating the hosts as much as the officials. Rangnick must rally his troops for an uphill battle to qualify for next season's Champions League by finishing in the top four after Tuesday's confident, determined start fizzled out. Cristiano Ronaldo showed skills on the cross in the first minute and then Elanga somehow found a cross in front of Oblak only for referee Slavko Vincic to rule a foul after the teenager missed the goal. The 19-year-old was agonizingly close to opening the scoring in the 13th minute when he smashed in a Bruno Fernandes cross with a first shot that Oblak blocked with his head. But the hosts' control began to loosen and they almost fell behind in the 34th minute when Alex Telles was caught napping as Koke played to Marcos Llorente, who was narrowly sidelined before finding Felix to score . Calls for a foul on Elanga fell on deaf ears as Atleti launched a considered, skillful attack that ended with Felix Griezmann chopping a cross to the back stick where Lodi headed past De Gea at his near post. Fernandes poked Oblak's palms from long range in injury time of the first half and Elanga hissed over goal just after the restart. De Gea showed his anger after getting into trouble from the hesitant Harry Maguire and having to save a try from De Paul before Fred hit wide and Jadon Sancho volleyed in against a side content to sit deep and to break. A whipped Fernandes free-kick just eluded Ronaldo before the former was withdrawn in a treble substitution that saw the introduction of Paul Pogba, Nemanja Matic and Marcus Rashford. Jose Maria Gimenez and Griezmann tried to score a second for Atletico which frustrated United as referee Vincic's decisions became enraged. Edinson Cavani came on as United chased an equalizer that came close in the 77th minute when Raphael Varane got up to head in from a Telles free-kick which Oblak impressively saved. Technical director Darren Fletcher was cautioned as Atleti ticked down the clock and advanced all the way to the quarter-finals at Old Trafford, where Simeone ran down the sideline and tunnel after full-time.

Read

Ralf Rangnick says the referee made it easy for Atletico to make 'time-wasting antics'

A brilliant United start faded and Renan Lodi put Atleti ahead as half-time approached. (Author: Gardener)

Ralf RangnickRalf Rangnick accused those in charge of making it "pretty easy" for Atletico Madrid to run down the clock with their "time-wasting antics" as Manchester United fell from the Champions League. Three weeks after a narrowly deserved 1-1 draw in Spain, Old Trafford rocked as the Red Devils attempted to reach the quarter-finals for the third time in a decade. But a brilliant start from United faded and Renan Lodi put Atleti ahead as half-time approached, with Diego Simeone's nimble, well-trained side sitting deep to keep the hosts at bay in a goalless second half. The 1-0 win secured the Spaniards a place in the quarter-finals and interim boss Rangnick couldn't hide his frustration with referee Slavko Vincic afterwards. "I think we played a good first half," said the German. “The only thing we haven't achieved is converting that energetic performance into the first goal and against a team like Atletico it's very important that you score the first goal yourself. “If you don't do that then it's even more important not to concede and we conceded that goal just before half-time in a transitional moment. "I think there was a foul on Anthony Elanga before that, but the referee and linesman didn't see it that way. "I think we shouldn't have been 1-0 down at half-time. We were the better team in the first half, but as I said, it's important to score first, especially against a team like Atlético. "In the second half, I don't know if the game went more than two minutes without being interrupted by someone lying on the ground. "But I think he made it pretty easy for Atletico to pull off his time-wasting antics and that didn't make it any easier for us. "It was frustrating, difficult for us in the second half. "We had two or three moments from set pieces but we didn't create that many chances from normal play." Rangnick didn't believe his side had shown any naivety in the second half, saying Atletico are probably "the masters of this style of football" as he stressed it wasn't easy to "break that wall". "It's unusual not to play a single game in two and a half weeks, even more so in this league when you play every three days," said Rangnick. “We have 85 per cent of the squad on international duty and most of them don't come back until Tuesday and Wednesday so we end up with three days to prepare for the Leicester game. "Obviously we have to win at Arsenal but the only way to end up fourth is to win most of those nine games." The celebrations of Atletico fans could be heard in the background as press conferences began at Old Trafford , where objects were thrown at Simeone as he ran straight through the tunnel full-time. "When I came off the pitch I ran because I was happy and I like enjoying it in the dressing room, so I don't know what happened (with objects being thrown at me)," said the Atleti boss. “I was just thinking about going to the dressing room and I was really happy. "We continued to control the game in the second half. And we felt more comfortable - we know our opponent plays well on the break, so we tried to reduce space. I didn't really have to make any changes because working together was so good today.”

Read